Following its 20–23 March meeting, WHO’s Strategic Advisory Group of Experts on Immunization (SAGE) revised the roadmap for prioritizing the use of COVID-19 vaccines, to reflect the impact of Omicron and high population-level immunity due to infection and vaccination. The roadmap continues SAGE’s prioritization of protecting populations at the greatest risk of death and severe disease from SARS-CoV-2 infection and its focus on maintaining resilient health systems. The roadmap newly considers the cost-effectiveness of COVID-19 vaccination for those at lower risk—namely healthy children and adolescents—compared to other health interventions. The roadmap also includes revised recommendations on additional booster doses and the spacing of boosters. The current COVID-19 vaccines’ reduction of post-COVID conditions is also considered but the evidence on the extent of their impact is inconsistent.
